microRNA in nascent platelet

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Iwate Medical University
• Principal Investigator: Kowata Shugo 岩手医科大学, 医学部, 講師 (30418884)
• Co-Investigator(Kenkyū-buntansha): 石田 陽治 岩手医科大学, 医学部, 助教授 (70151389)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 新生血小板 / Autophagy / microRNA

Outline of Final Research Achievements

Murine thrombocytopenia model showed that nascent platelets contained specific microRNAs. ROS triggered autophagy flux at megakaryocytic and nascent platelets, and autophagy regulated adequate distribution of cellular organelle and microRNAs in individual platelets. In human specimens, the ratio of autophagosome and RNA positive platelets were significant higher in immune thrombocytopenia. However, the ratio of autophagosome and microRNA positive platelets were significant lower in patients with myelodysplastic syndrome and aplastic anemia. Autophagy in nascent platelets may guarantee a quality of individual platelets via regulation of adequate distribution of cellular organelle and microRNAs in individual platelets.

Free Research Field

血小板産生