2017 Fiscal Year Final Research Report
A novel oncogenic function of Wilms tumor gene WT1 in leukemia
| Project/Area Number |
15K09476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
Oji Yusuke 大阪大学, 医学系研究科, 教授 (20294100)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | WT1 / leukemia |
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| Outline of Final Research Achievements |
In the present study, we showed that 1) WT1 protein, which is overexpressed in leukemia and various types of solid cancers, associated with metabolic enzymes in leukemia cells and 2) a small molecule targeting this association efficiently induced cell death in WT1-expressing leukemia cells. These results indicate that the association between WT1 protein and metabolic enzymes could be a novel target of molecule-targeted cancer therapy.
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| Free Research Field |
腫瘍生物学
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