Analysis of genetic abnormalities in adult T-cell leukemia/lymphoma and elucidation of its significance

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09479
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: University of Miyazaki
• Principal Investigator: Kubuki Yoko 宮崎大学, 医学部, 講師 (00284836)
• Co-Investigator(Kenkyū-buntansha): 北中 明 川崎医科大学, 医学部, 准教授 (70343308) ; 下田 和哉 宮崎大学, 医学部, 教授 (90311844)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ① 成人T細胞性白血病・リンパ腫 / TET2 / HBZ

Outline of Final Research Achievements

In this study, analyses were performed, focusing on mutation of TET2, an epigenetic regulator, which is observed in about 10% of ATLL and is expected to be involved in the disease onset and development. Clinical analysis between TET2 mutant patients and TET2 wild-type patients revealed that extranodal lesions were more frequent in the former than the latter. In mouse model analysis, organ infiltration of lymphocytes was more enhanced in HBZ-transgenic/TET2-mutant compound mice, compared to HBZ-transgenic mice that reflect HLTV-1 chronic infection. It seems that TET2 mutation accelerates organ infiltration of ATLL cells, resulting in the disease progression.

Free Research Field

血液内科学