2017 Fiscal Year Final Research Report
Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model system
| Project/Area Number |
15K09492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University (2016-2017)
Aichi Cancer Center Research Institute (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 悪性リンパ腫 / マウスモデル / レトロウイルス |
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| Outline of Final Research Achievements |
We have investigated causative roles of given genes or mutated genes in the development of malignant lymphoma and multiple myeloma using our high-throughput mouse model system, in which germinal center B cells (normal counterparts of many lymphomas) were induced in vitro, infected with retroviruses for gene of interest, and transplanted into mice. Results showed that a combination of CARD11 mutant and BCL6 or a combination of Myc and Bcl2 was sufficient for the development of lymphoma. Our models may provide a platform for the development of therapy of these lymphomas known as being associated with poor clinical outcome. Although we were unable to develop a mouse myeloma model within the assigned period of time, we have developed a Cre-LoxP-mediated gene expression system employing retrovirus vector, and thus will make an effort to accomplish the aims.
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| Free Research Field |
造血器腫瘍
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