2017 Fiscal Year Final Research Report
Analyses of immune tolerance mechanism in allogeneic transplantation
| Project/Area Number |
15K09493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 骨髄移植 / 制御性T細胞 / 移植片対宿主病 |
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| Outline of Final Research Achievements |
Regulatory T cells (Treg) regulate the immune system and enhance immune tolerance after transplantation. In this study, we demonstrated that a single treatment of the agonistic antibody to DR3 to donor mice resulted in the expansion of donor derived Treg and prevented acute GVHD. Further, we comprehensively analyzed the immunophenotype of Treg after DR3 signal activation, demonstrating that DR3 activated Treg had an activated/mature phenotype. However, DR3 activation in mice with ongoing GVHD further promoted donor T cell activation/proliferation. These data suggest that the function of DR3 signaling was highly dependent on the activation status of the T cells. Our data demonstrated that DR3 signaling affects the function of Treg and T cell activation after alloantigen exposure in a time-dependent manner.
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| Free Research Field |
血液内科学
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