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2017 Fiscal Year Final Research Report

Comprehensive analysis of GVHD regulated cells by high dimensional cytometry and identification of prognostic factors

Research Project

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Project/Area Number 15K09508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionSapporo Medical University

Principal Investigator

Murase Kazuyuki  札幌医科大学, 医学部, 講師 (90444918)

Co-Investigator(Kenkyū-buntansha) 佐藤 勉  札幌医科大学, 医学部, 講師 (40404602)
小船 雅義  札幌医科大学, 医学部, 准教授 (90336389)
Project Period (FY) 2015-04-01 – 2018-03-31
KeywordsGVHD / Treg / 高次元サイトメトリー
Outline of Final Research Achievements

In chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation, individual differences in severity are large, so identification of GVHD predictive factors and development of a novel control method are desired.
In this study, we comprehensively analyzed cGVHD regulatory cells after transplantation by using high-dimensional cytometry in combination with BH3 profiling and clarified the usefulness of IL-2 therapy.

Free Research Field

血液腫瘍

URL: 

Published: 2019-03-29  

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