2017 Fiscal Year Final Research Report
Comprehensive analysis of GVHD regulated cells by high dimensional cytometry and identification of prognostic factors
| Project/Area Number |
15K09508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 勉 札幌医科大学, 医学部, 講師 (40404602)
小船 雅義 札幌医科大学, 医学部, 准教授 (90336389)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | GVHD / Treg / 高次元サイトメトリー |
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| Outline of Final Research Achievements |
In chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation, individual differences in severity are large, so identification of GVHD predictive factors and development of a novel control method are desired.
In this study, we comprehensively analyzed cGVHD regulatory cells after transplantation by using high-dimensional cytometry in combination with BH3 profiling and clarified the usefulness of IL-2 therapy.
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| Free Research Field |
血液腫瘍
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