Proliferation and Differentiation of naive helper T cells by Dendritic cells in Human

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Tokyo Medical University
• Principal Investigator: NAGAI Taro 東京医科大学, 医学部, 講師 (60747674)
• Co-Investigator(Kenkyū-buntansha): 秦 喜久美 東京医科大学, 医学部, 講師 (30287156) ; 善本 隆之 東京医科大学, 医学部, 教授 (80202406)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 樹状細胞 / サイトカイン / T細胞

Outline of Final Research Achievements

Not only IFN-g which is Th1 cytokine but also IL-4 and IL-13 which are Th2 cytokine enhance the IL-12 production from a dendritic cell. IFN-g reinforces both the IL-12 production from DC and the IL-23 production. On the other hand, IL-4 and IL-13 reinforce the IL-12 production from DC, but the IL-23 production controls it.
IL-10 controls IL-12/23/27 production from DC. IL-10 controls dendritic cell cytokine-producing reinforcement action of IFN-g/IL-4/IL-13.
The cytokine-producing ability of the immature dendritic cell is inferior to a mature dendritic cell, but still is enough quantity for a T cell differentiation increase instruction.

Free Research Field

免疫学