2017 Fiscal Year Final Research Report
Functional analysis of genetic polymorphism associated with hematopoietic stem cell transplantation, and exploration for genome target therapy
| Project/Area Number |
15K09513
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 造血幹細胞移植 / 遺伝子多型 |
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| Outline of Final Research Achievements |
The immunomodulation-related gene polymorphism analysis of patients who received allogeneic bone marrow transplantation and their donor showed that the polymorphic sites of functional genes with clinical significance, including NKG 2D, CXCL10, NLRP 3, THBD/BDCA3, TLR1, TLR4, CCL2, were concentrated in the 5’-untranslated region. It was also revealed that miRNA-1245 binds to the polymorphic site of the 5’-untranslated region of the activated NK receptor gene NKG2D, leading to suppress NK activity, and that miRNA-1245 in serum exosomes obtained from patients with hematologic malignancies is increased. Moreover, the binding ability of miRNA-1245 with the low NK cytotoxicity genotype was superior to that with the high NK cytotoxicity genotype.
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| Free Research Field |
血液学
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