2017 Fiscal Year Final Research Report
Identification of novel proteins that bind to various immunosuppressive / immunomodulatory drugs and clinical implications in the immune system
| Project/Area Number |
15K09516
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
WAKUI Hideki 秋田大学, 理工学研究科, 教授 (70240463)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
布村 渉 秋田大学, 理工学研究科, 准教授 (70256478)
小松田 敦 秋田大学, 医学(系)研究科(研究院), 准教授 (70272044)
|
|---|
| Research Collaborator |
DOHMAE Naoshi
ODAKA Masafumi
MSTSUMURA Hirotoshi
OMOKAWA Ayumi
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 免疫抑制剤・免疫調節剤 / 薬剤アフィニティークロマトグラフィー / ヒト血液 / 動物臓器 / 薬剤結合蛋白質（標的蛋白質候補） / 新規薬理作用 / 臨床応用 / 温故知新創薬 |
|---|
| Outline of Final Research Achievements |
Clinical effectiveness and safely of widely used immunosuppressive / immunomodulatory drugs have been confirmed. Since these drugs are generally cheap, it is an important clinical issue to reassess their pharmacological actions from a pharmacoeconomical point of view.
In this study, several drugs widely used in the treatment of autoimmune diseases, such as rheumatoid arthritis, and allergic diseases are selected. Novel drug-binding proteins having important roles in the immune response processes (candidates for drug-target proteins) were identified. The results suggest novel pharmacological actions of these drugs and their clinical applications in the feature.
|
| Free Research Field |
内科学
|
