Development of a novel method for therapy against autoimmune disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Chiba University
• Principal Investigator: Sakamoto Akemi 千葉大学, バイオメディカル研究センター, 准教授 (90359597)
• Co-Investigator(Kenkyū-buntansha): 植松 智 千葉大学, 大学院医学研究院, 教授 (50379088) ; 藤村 理紗 千葉大学, バイオメディカル研究センター, 助教 (30376363) ; 幡野 雅彦 千葉大学, 大学院医学研究院, 教授 (20208523)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自己免疫疾患 / 転写因子 / 阻害剤

Outline of Final Research Achievements

We studied autoimmune disease related factors using animal model in this project. First we developed mouse autoimmune induced models. Among them experimental autoimmune encephalomyelitis (EAE) model represented symptoms.
We found that factor A was critical for development of experimental autoimmune encephalomyelitis because factor A CD4Cre knocked out mice did not show the symptom of the diseases. After searched inhibitors of factor A offered from small chemical library, we finally found several small chemicals as functional inhibitor. These results may useful for development of new therapeutic methods against autoimmune diseases.

Free Research Field

免疫学