The role of CD206 positive M2 macrophages in collagen antibody induced arthritis (CAIA)

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09523
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Toyama
• Principal Investigator: SHINODA Koichiro 富山大学, 大学院医学薬学研究部(医学), 助教 (40377312)
• Co-Investigator(Kenkyū-buntansha): 多喜 博文 富山大学, 大学院医学薬学研究部(医学), 准教授 (10240780) ; 朴木 博幸 富山大学, 附属病院, 助教 (90512088)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: rheumatoid arthritis / M2 macrophage

Outline of Final Research Achievements

Examining the role of M2 macrophages in rheumatoid arthritis (RA) is extremely　mportant in selecting treatment for this disease. In this study, it was　possible to investigate the localization of CD206 positive macrophages in arthritis locally using arthritis model mice. Interestingly, CD206 expression could be observed in osteoclasts and synovial type A cells in arthritic joints. CD206 positive M2 macrophages might had different role in RA from the assumption of anti-inflammatory roles of M2 macrophages.

Free Research Field

Rheumatology