2017 Fiscal Year Final Research Report
Detection of biomarkers in pre-treatment serum which predict the clinical remission on the treatment with biologics in rheumatoid arthritis.
| Project/Area Number |
15K09524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バイオマーカー / 治療効果予測 / 関節リウマチ / トシリズマブ / インフリキマム |
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| Outline of Final Research Achievements |
Rapid progress of RA therapy has been made with molecular inhibitors.However simultaneously, many kinds of biologics were developed, then it has been difficult to select the adequate biologic by both physicians and patients. Therefore we try to detect the makers in serum before starting therapy which can predict the actual efficacy of biologics.
In result, in the case of anti TNF-α inhibitor therapy, the efficacy has been able to predicted on the statistical analysis using Lasso method.Now we know the individual efficacy by selected biologic.
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| Free Research Field |
医歯薬学
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