Role of effector B cells and regulatory B cells in the pathogenesis of autoimmune diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09528
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kyushu University
• Principal Investigator: NIIRO HIROAKI 九州大学, 医学研究院, 教授 (20380636)
• Co-Investigator(Kenkyū-buntansha): 赤司 浩一 九州大学, 医学研究院, 教授 (80380385)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自己免疫疾患 / B細胞 / 免疫学

Outline of Final Research Achievements

The advent of B cell-targeting therapy underscores a novel Ab-independent role of B cells in the pathogenesis of rheumatoid arthritis (RA). In this study we identified two distinct B cell subsets, RANKL-producing effector B cells (Beff) and IL-10-producing regulatory B cells (Breg), and elucidated the molecular mechanisms of induction of these subsets and their roles played in RA.

Free Research Field

リウマチ学