2017 Fiscal Year Final Research Report
Novel strategies for treatment of rheumatic diseases by Wnt signal blockades
| Project/Area Number |
15K09541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
和泉 弘人 産業医科大学, 産業生態科学研究所, 准教授 (50289576)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | リモデリング抑制 / Wnt10 / 膠原病 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the mechanism of EMT and EndoMT in tissue remolding and fibrosis of rheumatic diseases and to develop a new treatment strategy for rheumatic diseases.
We conducted immune-staining of skin, lung and kidney tissue from rheumatic disease including rheumatoid arthritis, systemic sclerosis and vasculitis. As a result, a hyperplasia of myofibroblast was observed at the site of prominent proression of tissue fibrlsis and vascular reumodeling due to endothelial dell proliferation. Immuno-staining revealed both the myoblast and endothelial cells express Wnt10A, suggesting signaling through Wnt10A might involvement in irreversible remodeling in rheumatic diseases. These provocative findings suggest that the inhibition of EndMT/EMT may be a promising target for clinical therapeutic translation in settings such as tissue remodelilng which cause of irreversible organ damage in rheumatic diseases.
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| Free Research Field |
医歯薬学
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