AIT efficacy regulated by the circadian clock in mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09548
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAMURA Yuki 山梨大学, 大学院総合研究部, 准教授 (90580465)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 花粉症 / 概日時計

Outline of Final Research Achievements

We have been showed that the circadian clock regulates symptoms of some allergic diseases exhibit prominent variations with a period of approximately 24 h [JACI 2011, 2014]. Based on these studies, this study performed whether the effect of time of day on AIT [Antigen specific Immunotherapy] efficacy with the goal of optimizing the therapeutic outcome in the mouse model of allergic rhinitis. In the AR model, mice sublingually receiving an antigen during resting phase exhibited a greater decrease in antigen-specific IgE levels than mice treated during waking phase or in a random manner. In addition, mice treated during resting phase exhibited reductions in antigen-specific cytokine production by splenocytes relative to mice treated during waking phase or in a random manner. These results suggested that the circadian clock regulates AIT to maximize its effectiveness.

Free Research Field

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