Immunonutritional therapy by induced gamma delta T cell in patients with cancer chemotherapy

2019 Fiscal Year Final Research Report

• Project/Area Number: 15K09570
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kagawa University
• Principal Investigator: Imataki Osamu 香川大学, 医学部附属病院, 講師 (60437697)
• Co-Investigator(Kenkyū-buntansha): 植村 麻希子 香川大学, 医学部, 助教 (00710188)
• Project Period (FY): 2015-04-01 – 2020-03-31
• Keywords: adaptive cell therapy

Outline of Final Research Achievements

Among the lymphocyte fractions in the tumor cells of patients undergoing cancer chemotherapy for hematological malignancies, helper T cells and B cells significantly affected patients’ survival. γδT cells are a very small component in these lymphocyte fractions, and their effects on clinical outcome were not fully analyzed.

Free Research Field

Immunotherapy

Academic Significance and Societal Importance of the Research Achievements

腫瘍組織局所の免疫状態はがん種によって異なると考えられた。また骨髄内と腫瘍組織において増殖する細胞も異なっていた。血液悪性腫瘍においては生存に寄与する骨髄内リンパ球分画が見いだせなかったが、腫瘍組織において正常のヘルパーT細胞やB細胞の浸潤が予後に関連している可能性が考えられた。