Development of novel therapeutic strategies to overcome refractory fungal infections

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K09573
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: MIYAZAKI Taiga 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60448496)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 抗真菌薬

Outline of Final Research Achievements

In the context of limited availability of antifungal agents, the emergence of multidrug resistant isolates has become a critical issue in clinical settings, underscoring an urgent need for the development of new antifungal strategies.
In this study, we have elucidated the resistant mechanisms of multidrug resistant Candida glabrata and the clinical and microbiological characteristics of Candida guilliermondii infections. In addition, we performed high-throughput screening of chemical compound libraries and found a novel compound that had potent antifungal activities.

Free Research Field

感染症内科学

Academic Significance and Societal Importance of the Research Achievements

侵襲性真菌感染症は致死的な経過をとることも少なくない。治療薬が少ないなかで耐性菌の出現が問題となっている。今回、耐性化のメカニズムや耐性菌感染症の臨床的および微生物学的特徴を一部解明した。また、化合物ライブラリーのスクリーニングにより、病原真菌に有効な新規化合物を同定することができた。これらの研究成果は、今後の新薬開発に寄与するものと考える。