Immunological activation and bone mineral loss in patients with HIV

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Teikyo University
• Principal Investigator: Ota Yasuo 帝京大学, 医学部, 教授 (80292936)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HIV / 骨密度 / cART

Outline of Final Research Achievements

Clinical factors that were related to bone mineral density (BMD) loss in 31 HIV patients who started cART were studied. Tenofovir and protease inhibitors were related to BMD loss one year after initiation of cART. In addition, BMD loss decreased larger in HIV patients with lower CD4 T lymphocytes, suggesting that immunological activation might play some roles in BMD loss. However, LPS-induced monocyte activation was not associated with CD4 T lymphocytes counts. We need to take some measures that prevent from BMD loss especially in patients with low CD4 T lymphocytes counts.

Free Research Field

感染症内科学