2017 Fiscal Year Final Research Report
Study the role of mucosal immunity of intestine in bacterial translocation
| Project/Area Number |
15K09584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バクテリアルトランスロケーション / 粘膜免疫 / 炎症性腸疾患 / NKT細胞 |
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| Outline of Final Research Achievements |
Bacterial translocation (BT) is the phenomenon of invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and the internal organs. The mucosal immune response in the intestine might play a role in BT. Therefore, the aim of this study was to evaluate the NKT cell in the relation to BT by using mouse model of inflammatory bowel disease (IBD). Mortality rate of CD1d knockout mice which lack NKT cells was significantly lower than that of control mice. Evaluation of the body weight changes and bloody stool score after the induction of IBD suggested that the more severe inflammation was shown in the wild type control mice. These results suggested that NKT cells may play a role in the progression of IBD.
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| Free Research Field |
感染症、微生物学、免疫学
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