The prevalence and findings of subclinical influenza-associated cardiac abnormalities among Japanese patients.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09588
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Osaka Medical College
• Principal Investigator: Takahide Ito 大阪医科大学, 医学部, 講師 (00319550)
• Co-Investigator(Kenkyū-buntansha): 石坂 信和 大阪医科大学, 医学部, 教授 (20270879) ; 浮村 聡 大阪医科大学, 医学部, 教授 (50257862) ; 寺崎 文生 大阪医科大学, 医学部, 教授 (20236988)
• Research Collaborator: KANZAKI Yumiko 大阪医科大学, 医学部, 講師 (80445999)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: influenza / cardiac function / electrocardiogram / echocardiogram / cardiac enzymes

Outline of Final Research Achievements

Although life-threatening cardiac complications are rare in influenza infection, subclinical influenza-associated cardiac abnormalities may occur more frequently. A total of 102 subjects underwent a first set of examinations, including electrocardiography (ECG), echocardiography, and the measurement of cardiac enzyme levels. Those with one or more abnormal findings among these examinations were encouraged to undergo a repeat examination 2 weeks later. Among the 102 subjects, 20 (19.6%) were judged to have cardiac findings, those including ST-T abnormalities, pericardial effusion, diastolic dysfunction, and cardiac enzyme elevation. Eighteen of these 20 subjects underwent a second screening, and 11 of the 18 subjects were found free from cardiac findings. In conclusion the cardiac findings after influenza infection were only mild and transient; however, physicians should be aware of influenza infection-associated cardiac abnormalities because such abnormalities may not be rare.

Free Research Field

循環器全般