2017 Fiscal Year Final Research Report
A prospective randomized control study of combination therapy with methimazole and a cholesterol absorption inhibitor as for the initial treatment of childhood-onset Graves disease
| Project/Area Number |
15K09616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バセドウ病 / ランダム化比較試験 / 介入研究 / メチマゾール / コレステロール吸収阻害剤 |
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| Outline of Final Research Achievements |
For the first time worldwide, a randomized controlled trial was initiated to determine whether the combination therapy of methimazole, an antithyroid agent, and a cholesterol absorption inhibitor was useful as an initial therapy for patients with a new onset of childhood Graves’ disease with moderate-to-severe hyperthyroidism.
The target number of patients was 70 patients, with 51 patients having been enrolled so far. At the beginning of the trial, 26 facilities were included for participation, but currently, 41 facilities are included, and the research protocol is in place. However, the target number of patients has not been reached. Therefore, we plan to extend the research period, without continuing the interim analysis.
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| Free Research Field |
内分泌学
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