2017 Fiscal Year Final Research Report
Investigation for pathogenesity of "osteolysis" in multcentric carpotarsal osteolysis
| Project/Area Number |
15K09623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Okayama University |
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Principal Investigator |
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| Research Collaborator |
HIGUCHI Yousuke
YAMASHITA Miho
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 骨形成 / 骨吸収 |
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| Outline of Final Research Achievements |
We conducted functional analysis of Wild and mutant (T62P and R63G) in MC3T3E1 and ATDC5. Overexpression of wild MafB induced apoptosis in MC3T3E1. In ATDC5, we analyzed runx2 mRNA expression before confluent state and after confluent state and we observed different runx2 mRNA expression according to the differentiation stage (Before confluent state, wild=T62P>R63G; after confluent state, runx2 R63G>T52P>wild).
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| Free Research Field |
小児内分泌
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