Prediction of DiabetesMellitus by using with iPS cell technology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kumamoto University
• Principal Investigator: MATSUMOTO SHIROU 熊本大学, 大学院生命科学研究部(医), 准教授 (70467992)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA KIMITOSHI 熊本大学, 大学院生命科学研究部小児科学分野, 教授 (30336234) ; KIDO JUN 熊本大学, 医学部附属病院小児科学分野, 特任助教 (70721215)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 小児糖尿病 / iPS細胞 / エネルギー代謝

Outline of Final Research Achievements

We tried to establish for prediction of DiabetesMellitus by using with iPS cell technology and novel therapeutic strategy with stem cells. We could isolated iPS cells originated from healthy control and type 1 Diabetes Mellitus, which were differentiated into beta cells. We could establish the way to purify the insulin producing cells and expansion methods with these iPS cells. We could also establish the method of mass culture suitable to clinical therapy. In addition, we analyzed metabolome investigation in beta cells differentiated from iPS cells and it is indicated that mitochondrial dysfunction may influence type 1 diabetes.

Free Research Field

内分泌・代謝・再生医療