Elucidation of immunological pathophysiology of non-herpetic acute limbic encephalitis: IgG subclass-complement dependent disorder

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: Takahashi Yukitoshi 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (70262764)
• Research Collaborator: NISHIMURA Shigeko ; TAKAO Emiko ; KASAI Risa ; ENOKIDA Kaoru
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 非ヘルペス性急性辺縁系脳炎 / 免疫病態 / GluN2B抗体 / GluN1抗体 / IgGサブクラス / 活性化補体 / 免疫複合体

Outline of Final Research Achievements

Results: Before immunomodulation therapy (IT), mean level of C5a of NHALE was higher than that of DCs (p=0.0271), and 36.8% of patients had higher levels than mean+2SD of DCs. Evolution of C5a suggested peak level around 10 days after onsets.
Before IT, mean level of iC3b in NHALE was higher than that of DCs(p<0.0001), and 66.7% of patients had higher levels than mean+2SD of DCs. Evolution of iC3b suggested peak level around 10 days after onsets. Before IT, mean level of MAC in NHALE was higher than that of DCs (p<0.0001), and 51.4% of patients had higher levels than mean+2SD of DCs. The mean level in NHALE was also higher (p=0.0003) after IT. Before & after IT, mean level of CD59 was not different between two groups. Conclusion: In approximately half of NHALE patients, increased activated complements may contribute to the impairment of neuronal cells in acute stage.

Free Research Field

神経免疫