2017 Fiscal Year Final Research Report
Recovery of thymus function using cultured mast cells: prevention of lethal chronic graft-versus-host disease
Project/Area Number |
15K09643
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Kanazawa University |
Principal Investigator |
|
Research Collaborator |
ARAKI Raita
KURODA Rie
MASE Shintaro
MAEBA Hideaki
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 慢性GVHD / 肥満細胞 |
Outline of Final Research Achievements |
Refractory hematological malignancies have been cured by the progress of hematopoietic stem cell transplantation, however graft-versus-host disease (GVHD) is still an obstacle. We have studied the pathophysiology of GVHD using a rodent model to develop new treatments, especially focusing in chronic GVHD probably caused by functional impairments of thymus. In this study, we have indicated that host-typed mast cells are involved in the recovery of thymus function using mast cell deficient mice.
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Free Research Field |
造血幹細胞移植
|