Studies on the mechanisms of activation and inactivation of factor VIII: Applications of novel (anti-)coagulant therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nara Medical University
• Principal Investigator: Nogami Keiji 奈良県立医科大学, 医学部, 准教授 (50326328)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 第VIII因子 / トロンビン / 活性型第VII因子 / 組織因子 / 凝固機序 / 活性化 / 第X因子

Outline of Final Research Achievements

Regards the coagulant factor (F)VIII protein that is essential to both sides of hemorrhage and hemostasis in the blood coagulation, we for the first time identified the thrombin-binding sites responsible for the cleavages at Arg372 and Arg1689 in the FVIII activation. In addition, in terms of activated FVII/tissue factor (FVIIa/TF), we found not only the extrinsic-related coagulation mechanism, the intrinsic-related coagulation mechanism by the FVIII-FVIa/TF-related regulation exerts, consequently both mechanisms function in the initial phase of coagulation process.

Free Research Field

血栓止血