2017 Fiscal Year Final Research Report
Establishment of treatment strategies for early-onset inherited arrhythmias based on genotype-phenotype relationships
| Project/Area Number |
15K09680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
HORIE Minoru 滋賀医科大学, 医学部, 教授 (90183938)
LIN Lisheng 茨城県立こども病院, 小児循環器科, 医長
KAMEDA Yuri
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 遺伝性不整脈 / 先天性QT延長症候群 / 遺伝子型 / 心電図 / 独立成分分析 / 主成分分析 |
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| Outline of Final Research Achievements |
Congenital long QT syndrome (LQTS) is considered to be implicated in the development of sudden infant death syndrome (SIDS). Mutation sites of early-onset LQTS (type 2 and 3) were compared with those detected in SIDS victims. The locations were completely different between the two groups for LQT2, and only four mutations overlapped each other for LQT3. These dissociations might be due to difference in vulnerable age, small number of subjects of the study, and that environmental or other factors are required for development of SIDS.
T waves in patients with LQTS were evaluated by independent component analysis (ICA) and principle component analysis (PCA) of the data obtained by high-frequency ECG. The number of independent component was 4 in control subjects while 5-7 in LQTS patients. PCA ratios were also significantly higher in LQTS. ICA/ PCA might be useful for detection of heterogeneity of repolarization in LQTS.
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| Free Research Field |
小児循環器病学
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