2017 Fiscal Year Final Research Report
Roll of innate immune system in vasculitis of Kawasaki disease
| Project/Area Number |
15K09681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
犬塚 亮 東京大学, 医学部附属病院, 講師 (00597560)
東邦 康智 東京大学, 医学部附属病院, 助教 (10586481)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 川崎病 / 血管炎 / 冠動脈 / 自然免疫 |
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| Outline of Final Research Achievements |
We performed in vivo investigation about the role of innate immune system in vasculitis of Kawasaki disease with CAWS-treated mouse model. Unfortunately, we found no statistically significant differences between the severity score of vasculitis wild type mice and TLR- knockout mice. We decided that the role of TLR system in Kawasaki disease vasculitis in relatively modest. We are going to continue the investigation about Kawasaki disease vasculitis through the immune system of thymus and T-cells.
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| Free Research Field |
小児循環器学
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