The role of neurogenic airway inflammation on the remission of asthma during the adolescent period

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09698
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Saitama Medical University
• Principal Investigator: Tokuyama Kenichi 埼玉医科大学, 医学部, 教授 (30237078)
• Co-Investigator(Renkei-kenkyūsha): UEDA Yutaka 埼玉医科大学, 医学部, 講師 (70438828) ; MORITA Eiji 埼玉医科大学, 医学部, 助教 (50438834) ; KOGA Takeshi 埼玉医科大学, 医学部, 助教 (80601731) ; ITANO Atsushi 埼玉医科大学, 医学部, 助教 (60751542)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 気管支喘息 / 寛解 / 思春期 / 気道炎症 / 神経原性炎症 / 呼気一酸化窒素 / フローボリューム曲線 / 気道可逆性

Outline of Final Research Achievements

The purpose of this study was to evaluate the reversible airflow limitation, eosinophilic airway inflammation and neurogenic inflammation in adolescent asthmatics in remission. The results were compared with those in asthmatics with current medication. When comparing lung functions after bronchodilators, the percentage of subjects, whose % predicted values of FEV1.0 was still low, was significantly higher in subjects in remission, suggesting the presence of airway remodeling in these subjects. FENO, a marker of eosinophilic airway inflammation, was comparable between subjects in remission and with current medication. The measurement of plasma CGRP, a potent neuropeptide, was just started while we could not perform any statistical analysis during the study period.

Free Research Field

小児アレルギー病学・小児呼吸器病学