2017 Fiscal Year Final Research Report
Spindle orientation control via caveolin1 and Ak2 in skin development
| Project/Area Number |
15K09741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nagoya University (2017)
Kyoto University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 細胞分裂軸制御 |
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| Outline of Final Research Achievements |
It has been reported that spindle orientation control in skin basal cells has a pivotal role in skin development. Caveolin1, Ak2 and Pank2 are candidates, involved in spindle orientation control by our screen in adherent cultured cells. We hypothesized that these genes have a role in a common spindle orientation regulatory pathway, especially in metabolic pathway in sugar and lipids. However, although the inhibition of metabolic pathway resulted in spindle disregulation, we could not find a common pathway behind three candidate genes. We found that spindle misorientation in skin basal cells during embryonic skin development in caveolin1 ko mice. But we could not obtained Ak2 floxed homo mice at last and could not obtain any results if Ak2 regulates spindle orientation in skin development. To elucidate further insights, studies on more detailed analysis in metabolisms should be required.
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| Free Research Field |
細胞生物学
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