2017 Fiscal Year Final Research Report
The role of epidermal Langerhans cells and apoptotic cells in the termination of UV-induced cutaneous inflammation
| Project/Area Number |
15K09742
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Hatakeyama Mayumi
Washio Ken
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 紫外線 / 炎症 / ランゲルハンス細胞 / アポトーシス / 貪食 / 角化細胞 |
|---|
| Outline of Final Research Achievements |
Skin disorders caused by ultraviolet are observed as "sunburn" as an acute reaction. "Sunburn" is a risk factor of developing skin cancer. In this study, we focused on the role of epidermal Langerhans cells (LCs) and the UV-induced apoptotic keratinocyte in the outermost layer of the skin in relation to the termination of the UV-induced cutaneous inflammation. This study demonstrated that LC and apoptotic keratinocytes plays a role in suppression of UV-induced cutaneous inflammation. The inflammatory suppression mechanism and signal are mediated by LC phagocytosis of apoptotic keratinocytes.
|
| Free Research Field |
Dermatology
|
