Elucidation of the role of lipid rafts in the pathophysiology of pemphigus vulgaris

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: Saito Masataka 慶應義塾大学, 医学部(信濃町), 講師 (30306774)
• Co-Investigator(Kenkyū-buntansha): 山上 淳 慶應義塾大学, 医学部(信濃町), 講師 (80327618)
• Research Collaborator: KOWALCZYK AP 米国エモリー大学, 医学部, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 尋常性天疱瘡 / デスモゾーム / 脂質ラフト / 細胞内シグナル

Outline of Final Research Achievements

It was suggested that enlargement of the size of lipid rafts as a result of clustering of desmoglein (Dsg) 3 molecules was significant to function as a signaling platform in the pathogenesis of pemphigus vulgaris, although the relationship among desmosomal proteins other than Dgs3, cellular signaling molecules and lipid rafts is yet to be elucidated.

Free Research Field

自己免疫性水疱症