Study toward the complete therapy of palmoplantar keratoderma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09768
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka Ohtani University (2016-2017); Kagawa University (2015)
• Principal Investigator: Yoneda Kozo 大阪大谷大学, 薬学部, 教授 (60260626)
• Co-Investigator(Kenkyū-buntansha): 窪田 泰夫 香川大学, 医学部, 教授 (10126047) ; 中井 浩三 香川大学, 医学部附属病院, 講師 (40363204)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 薬物治療学 / 掌蹠角化症

Outline of Final Research Achievements

This study is finding the ultimate curative drug for palmoplantar keratoderma. The cost for creating disease model cells is far cheaper than creating knock mouse. We created the stable transformants expressing wild type connexin 26 protein and mutant connexin 26 protein. Next, the signal transduction was analyzed in both transformants. We are going to find candidate drugs which inhibit abnormal proliferation and keratinization in stable transformants expressing mutant connexin 26 protein.

Free Research Field

皮膚科学