2017 Fiscal Year Final Research Report
Androgen receptor target therapy of extramammary Paget's disease
| Project/Area Number |
15K09798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古村 南夫 久留米大学, 医学部, 准教授 (10315070)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 乳房外ページェット病 / 男性ホルモン / アンドロゲン受容体 / 表皮成長因子受容体 |
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| Outline of Final Research Achievements |
Although numerous cancer cell lines have already been established, to the best of our knowledge, the extramammary Paget’s disease (EMPD) cell line has not been established. EMPD cells also express glandular differentiation markers including carcinoembryonic antigen. In this study, we established EMPD cell line (EMPE cell) from typical EMPD skin lesions of an 82-year-old male. Androgen receptor is expressed in EMPE cell, but not Her2/neu proteins. EMPE cell showed positive growth effect by androgen and also EGF. EMPE cells should be extremely useful in the future studies of EMPD.
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| Free Research Field |
細胞生物学
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