2017 Fiscal Year Final Research Report
Gene expression analysis in monozygotic twins discordant for schizophrenia and control twins
| Project/Area Number |
15K09800
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
Nishimura Fumichika 東京大学
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 統合失調症 / 一卵性双生児不一致例 / mRNA発現 / リンパ芽球 |
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| Outline of Final Research Achievements |
Schizophrenia is a severe mental disorder of which molecular mechanisms must be clarified. If there were biological differences between the monozygotic twins discordant for the illness, the differences might be the clues. In this study, we showed the possibility that the differences of mRNA expression profiles in lymphoblastoid cells existed between the monozygotic twins discordant for schizophrenia, and further, we suggested DPYD and IGHM as the candidate genes for schizophrenia.
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| Free Research Field |
精神神経科学
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