Epigenetic effects of early life stress on adult hippocampal neurogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09805
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kobe University
• Principal Investigator: Boku Shuken 神戸大学, 医学研究科, 講師 (60455665)
• Co-Investigator(Kenkyū-buntansha): 菱本 明豊 神戸大学, 医学研究科, 准教授 (50529526)
• Co-Investigator(Renkei-kenkyūsha): Murai Toshiya 京都大学, 大学院医学研究科, 教授 (30335286) ; Furuyashiki Tomoyuki 神戸大学, 大学院医学研究科, 教授 (20362478) ; Izumi Takeshi 北海道大学, 大学院医学研究科, 講師 (60312360) ; Toda Hiroyuki 防衛医科大学校, 医学部, 助教 (00610677)
• Research Collaborator: Hiroi Noboru アルバートアインシュタイン医科大学, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 幼少期ストレス / DNAメチル化 / 成体海馬神経細胞新生

Outline of Final Research Achievements

1. We showed that some miRNA-related molecules may be involved in early life stress-induced increase of DNA methylation in adult hippocampal neural stem cell.
2. We showed that early life stress remarkably increased DNA methylation of gene region X with genome-wide analysis of DNA methylation. In addition, we showed that DNA methylation of gene region X may be associated with stress sensibility with behavioral analysis.
3. We are showing that DNA methylation may be associated with the assessment scale for early life stress in human subjects.

Free Research Field

精神医学、神経科学、精神神経薬理学