2017 Fiscal Year Final Research Report
The effects of phosphorylation on degradative processes of abnormally accumulated intracellular protein in dementia
| Project/Area Number |
15K09828
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森原 剛史 大阪大学, 医学系研究科, 助教 (90403196)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | タウ蛋白 / TDP-43 / リン酸化 / 認知症 |
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| Outline of Final Research Achievements |
Degradative processes of abnormally accumulated intracellular protein in dementia, are still unknown. We studied effects of phosphorylation of the protein on the degradative processes. Ubiquitination and its priming proteolysis of tau was not affected by phosphorylation. Proteolysis of TDP-43 by caspase was not affected by phosphorylation. However incorporation of tau into lysosome in chaperone-mediated autophagy was increased by PKA-phosphorylation. It is suggested that some of degradative processes of tau might be affected by its phosphorylation.
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| Free Research Field |
老年精神医学
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