Clinical research on argyrophilic grain disease in psychogeriatrics

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09831
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Okayama University
• Principal Investigator: Terada Seishi 岡山大学, 医歯薬学総合研究科, 准教授 (20332794)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: 老年精神医学 / 認知症 / 嗜銀顆粒病 / 陽性感情 / 陰性感情 / こころの理論

Outline of Final Research Achievements

We showed that early clinical manifestations of argyrophilic grain disease (AGD) included psychotic and mood symptoms as well as memory disturbance. Additionally, we reported that patients with AGD frequently exhibits mild neuropathological findings of progressive supranuclear palsy.
We clarified the differences in the frequencies of positive and negative affect between Alzheimer’s disease dementia (ADD), dementia with Lewy bodies, and vascular dementia. Positive affect scores of patients with ADD showed a significant correlation with regional cerebral blood flow in the left premotor region. We for the first time found the disturbance of the first-order theory of mind skills in the mild stage of ADD.

Free Research Field

老年精神医学，認知症