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2018 Fiscal Year Annual Research Report

Detecting cortical gamma band oscillation deficit in first-episode schizophrenia and clinical high risk subjects

Research Project

Project/Area Number 15K09836
Research InstitutionKyushu University

Principal Investigator

平野 羊嗣  九州大学, 大学病院, 助教 (90567497)

Co-Investigator(Kenkyū-buntansha) 神庭 重信  九州大学, 医学研究院, 教授 (50195187)
Project Period (FY) 2015-04-01 – 2019-03-31
Keywords統合失調症 / ハイリスク群 / ガンマオシレーション / ガンマ帯域皮質活動 / 脳波 / バイオマーカー / 脳機能 / 神経発達障害仮説
Outline of Annual Research Achievements

本研究によって、①音に対する早期の脳内情報処理に関わるガンマ帯域皮質活動(ガンマオシレーション)が、初発統合失調症では発症後に進行性に障害されることを発見した。さらに、前駆状態を含むハイリスク群では、その進行性の障害が認められなかった(Schizophr Res, 2019)。これにより、統合失調症の発症後に、既知の進行性の脳構造異常に加え、進行性の聴覚情報処理に関わる脳機能異常が生じていることが示唆され、統合失調症の進行性の神経発達障害仮説を裏付ける重要な知見が得られた。

その他、本研究の一環として、以下のような報告ならびに研究に発展した:②fMRIを用いた急性期統合失調症のASSR異常の発見(EBioMedicine 2017)、③統合失調症のθ-γ帯域皮質活動に関する位相-振幅変調異常の同定(Biol Psychiatry CNNI 2018)、④てんかん性精神病における精神病症状の主座の同定(Brain Imaging Behav 2019)、⑤統合失調症の大規模共同研究(脳形態:Neuroimage Clin 2017, NPJ Schizophr 2017、社会機能:Schizophr Res 2018, PCN 2017、眼球運動:Schizophr Res 2018)、⑥気分障害におけるγ帯皮質活動異常についての研究(J Affect Disord 2016)、⑦統合失調症の聴覚判別機能に関する研究、⑧アジア精神病研究コンソーシアムの整備(東京大学・ソウル大学・台湾大学等)、⑨脳波-fMRI同時測定による、時間的および空間的な脳活動の主座の解明。

  • Research Products

    (16 results)

All 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results)

  • [Int'l Joint Research] Harvard Medical School/University of Massachusetts(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      Harvard Medical School/University of Massachusetts
  • [Int'l Joint Research] National Taiwan University(中国)

    • Country Name
      CHINA
    • Counterpart Institution
      National Taiwan University
  • [Int'l Joint Research] The University of New South Wales(オーストリア)

    • Country Name
      AUSTRIA
    • Counterpart Institution
      The University of New South Wales
  • [Journal Article] Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals2019

    • Author(s)
      Oribe Naoya、Hirano Yoji、del Re Elisabetta、Seidman Larry J.、Mesholam-Gately Raquelle I.、Woodberry Kristen A.、Wojcik Joanne D.、Ueno Takefumi、Kanba Shigenobu、Onitsuka Toshiaki、Shenton Martha E.、Goldstein Jill M.、Niznikiewicz Margaret A.、McCarley Robert W.、Spencer Kevin M.
    • Journal Title

      Schizophrenia Research

      Volume: In Press Pages: -

    • DOI

      10.1016/j.schres.2019.03.025

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study2019

    • Author(s)
      Hirakawa Noriaki、Kuga Hironori、Hirano Yoji、Sato Jinya、Oribe Naoya、Nakamura Itta、Hirano Shogo、Ueno Takefumi、Oda Yuko、Togao Osamu、Hiwatashi Akio、Honda Hiroshi、Kanba Shigenobu、Onitsuka Toshiaki
    • Journal Title

      Brain Imaging and Behavior

      Volume: In Press Pages: -

    • DOI

      10.1007/s11682-019-00044-4

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia2018

    • Author(s)
      Morita Kentaro、Miura Kenichiro、Fujimoto Michiko、Shishido Emiko、Shiino Tomoko、Takahashi Junichi、Yamamori Hidenaga、Yasuda Yuka、Kudo Noriko、Hirano Yoji、Koshiyama Daisuke、Okada Naohiro、Ikeda Manabu、Onitsuka Toshiaki、Ozaki Norio、Kasai Kiyoto、Hashimoto Ryota
    • Journal Title

      Schizophrenia Research

      Volume: 202 Pages: 420~422

    • DOI

      10.1016/j.schres.2018.06.064

    • Peer Reviewed
  • [Journal Article] Phase-Amplitude Coupling of the Electroencephalogram in the Auditory Cortex in Schizophrenia2018

    • Author(s)
      Hirano Shogo、Nakhnikian Alexander、Hirano Yoji、Oribe Naoya、Kanba Shigenobu、Onitsuka Toshiaki、Levin Margaret、Spencer Kevin M.
    • Journal Title

      Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

      Volume: 3 Pages: 69~76

    • DOI

      10.1016/j.bpsc.2017.09.001

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Creativity and arts in psychiatry2018

    • Author(s)
      Hirano Yoji、Hosaka Kenjiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Pages: 1~1

    • DOI

      10.1111/pcn.12617

    • Peer Reviewed
  • [Journal Article] Artwork Description2018

    • Author(s)
      Hosaka Kenjiro、Hirano Yoji
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Pages: 132~132

    • DOI

      10.1111/pcn.12619

  • [Journal Article] Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia2018

    • Author(s)
      Isomura Shuichi、Hashimoto Ryota、Nakamura Motoaki、Hirano Yoji、Yamashita Fumio、Jimbo Shin、Yamamori Hidenaga、Fujimoto Michiko、Yasuda Yuka、Mears Ryan P.、Onitsuka Toshiaki
    • Journal Title

      npj Schizophrenia

      Volume: 3 Pages: eCollection

    • DOI

      10.1038/s41537-016-0008-y

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Progressive spontaneous and synchrony gamma-band oscillation deficits in first episode schizophrenia (SIRS Young Investigator Award)2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The 2018 Congress of The Schizophrenia International Research Society
    • Int'l Joint Research / Invited
  • [Presentation] Abnormal cortical activities in psychosis: toward translational research.2018

    • Author(s)
      Yoji Hirano, Kevin Spencer
    • Organizer
      21st International Conference on Biomagnetism
    • Int'l Joint Research / Invited
  • [Presentation] Neural Oscillation Abnormalities in Psychosis (Cutting-edge translational research in schizophrenia -from neurophysiological perspective-)2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The 40th Annual Meeting of JSBP
    • Int'l Joint Research / Invited
  • [Presentation] Abnormal Neural Oscillation and Auditory Hallucination in Schizophrenia2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The International Consortium on Hallucination Research 2018
    • Int'l Joint Research / Invited
  • [Presentation] 若手研究者育成プログラム:プログレスレポート2018

    • Author(s)
      平野羊嗣
    • Organizer
      第40回日本生物学的精神医学会
  • [Presentation] 統合失調症の神経生理学的研究 -ここまで分かった統合失調症-2018

    • Author(s)
      平野羊嗣
    • Organizer
      第13回日本統合失調症学会
    • Invited

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Published: 2019-12-27  

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