A prospective study of psychiatric symptoms before and after epilepsy surgery in patients with epilepsy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09851
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
• Principal Investigator: Nishida Takuji 独立行政法人国立病院機構(静岡・てんかん神経医療センター臨床研究部), その他部局等, その他 (00399586)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: てんかん / てんかん外科 / 精神症状 / 精神病 / うつ / 不安

Outline of Final Research Achievements

Psychiatric symptoms such as depression, anxiety and psychosis are common in patients with epilepsy. The pathogenesis of them are not known. In this study, psychiatric evaluation was performed in patients who had epilepsy surgery at the periods of pre-surgical evaluation, 3 months, 1 year, and 2 years after surgery. The psychiatric evaluation was completed in 130 patients at the periods of pre-surgical evaluation and 3 months, 1 year, and 2 years after surgery. Investigation was done in 79 patients with epilepsy surgery who were 16 years of age and older. Thirty two (41%) of 79 patients had psychiatric disorders before or after surgery. Fourteen (67%) of 21 patients who had any psychiatric disorders before surgery showed no psychiatric disorder at the time of 2 years after surgery. Eleven (19%) of 58 patients who had no psychiatric disorders at the pre-surgical evaluation showed any “de novo” psychiatric disorders during the 2 years post-surgical period.

Free Research Field

臨床てんかん学