2017 Fiscal Year Final Research Report
Development of a method of specifically predicting the onset of schizophrenia: An fMRI study on self-disturbance
| Project/Area Number |
15K09856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 和紀 東北大学, 医学系研究科, 准教授 (40301056)
杉浦 元亮 東北大学, 加齢医学研究所, 教授 (60396546)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Schizophrenia / Self─disturbance / Sense of agency / Forward model |
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| Outline of Final Research Achievements |
Self─disturbance is thought to be a highly specific disorder of schizophrenia and is also noted as an index for predicting later onset in psychosis risk state (ARMS). However, a method for objectively evaluating this has not been established yet. In this study, in order to evaluate Self─disturbance, we newly created a task applying the forward model of sensory result collation, and examined it in the patient group and healthy control group. Comparing the brain activity with the condition that the sensory result is different from the prediction and the condition that matches the prediction, the activation was performed in the upper temporal gyrus and Temporo-parietal junction in healthy volunteers, but activation was weak in patients. It is suggested that this result reflects the Self─disturbance and is expected as an indicator of future prognosis of psychosis risk status.
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| Free Research Field |
統合失調症
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