2018 Fiscal Year Final Research Report
A diffusion tensor imaging study of white matter in obsessive-compulsive disorder based on developmental disorder
Project/Area Number |
15K09871
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Chiba Prefectural University of Health Sciences |
Principal Investigator |
Sato Daisuke 千葉県立保健医療大学, 健康科学部, 講師 (00381682)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Keywords | 神経症 / 画像解析 |
Outline of Final Research Achievements |
In order to investigate changes in the white quality of obsessive compulsive disorder patients based on developmental disorders, we conducted a comparative study of obsessive-compulsive disorder patients based on developmental disorders and healthy controls using diffusion tensor imaging. As a result of comparing the fractional anisotropy of the obsessive-compulsive disorder patient group based on the developmental disorder and the healthy control group, fractional anisotropy tended to be significantly lower in cingulate gyrus in obsessive compulsive disorder patients with autism. There was no area where fractional anisotropy and obsessive compulsive symptoms were significantly correlated in obsessive comprehensive disorder patients with autism.
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Free Research Field |
精神神経科学
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Academic Significance and Societal Importance of the Research Achievements |
発達障害を併せ持つ強迫性障害の大脳白質の詳細な構造を調べることを目的に、脳の撮影画像を用い検討を行った。発達障害を併せ持つ強迫性障害と対照を比較した結果、白質繊維の束であり、大脳辺縁系の各領域を結びつける役割を担う帯状束に特徴的な差異が示された。一方で、強迫症状に関係する領域は示されなかった。このことから、発達障害を併せ持つ強迫性障害に帯状束の構造的な変化が関連する可能性が示唆された。
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