Construction of microcirculation and imaging evaluation method in intractable disease

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TATEISHI Ukihide 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (20415524)
• Research Collaborator: KANO Daisuke 国立研究開発法人 国立がん研究センター東病院, 薬剤部, 試験検査主任 (70392347) ; DOI Hisashi 国立研究開発法人理化学研究所, 神戸事業所ライフサイエンス技術基盤研究センター, チームリーダー (00421818)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Interim / Response

Outline of Final Research Achievements

Clarification of angiogenetic microcirculation in several subtypes of intractable diseases was tried using integrin-related RGD(Arg-Gly-Asp) peptide imgaing which is known as one of the angiogenetic surrogate markers. This PET probe enabled to evaluate earlier response to BV therapy in solid and non-solid tumor mouse models. As well as RGD peptide, correlation between mitotic activity and salvage TCA cycle metabolic imgaing were compared. There were variety in response to therapy, but response assessment could be performed safely and correctly using interim imaging methods.

Free Research Field

Molecular imaging