Development of radioiodine-labeled nanoparticle carrier with in vivo stability and tumor recognition ability for nuclear medicine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09903
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: YAMAMOTO Fumihiko 東北医科薬科大学, 薬学部, 教授 (40253471)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Shunsaku 京都大学, 工学研究科, 教授 (80150324) ; MAKINO Akira 福井大学, 高エネルギー医学研究センター, 准教授 (00566226)
• Research Collaborator: OZEKI Ei-ichi 株式会社島津製作所, 基盤技術研究所
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 分子イメージング / 腫瘍 / 放射性標識 / SPECT / 創薬

Outline of Final Research Achievements

Lactosome is nanocarrier with stealth and tumor recognition ability. We reported previously a successful in vivo imaging of mouse tumor of radio-labeled Lactosome as the preliminary study with using small animal PET or SPECT. However, its tumor uptake rate was slow and there was a suspicion that the biodistribution of radioactivity did not reflect that of Lactosomes.
As well as finding more stable radiolabeled lactosomes in vivo, improvement of drug design, such as high tumor recognition ability, is necessary in order to shorten the imaging time. In this study, we tried to find stable iodine-labeled lactosomes in vivo and synthesized radioactive lactosomes incorporating folate receptor ligand on its surface.

Free Research Field

放射性薬品化学、分子イメージング薬学