Blood oxygenation level-dependent contrast magnetic resonance imaging for prediction of overall survival in patients with pancreatic adenocarcinoma after chemoradiotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09931
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kagoshima University
• Principal Investigator: Fukukura Yoshihiko 鹿児島大学, 医歯学域医学系, 准教授 (50315412)
• Co-Investigator(Kenkyū-buntansha): 内匠 浩二 鹿児島大学, 医歯学域附属病院, 助教 (50535820) ; 袴田 裕人 鹿児島大学, 附属病院, 医員 (20727565) ; 中條 正豊 鹿児島大学, 医歯学域医学系, 助教 (00594631) ; 中村 文彦 鹿児島大学, 医歯学域附属病院, 助教 (00595738) ; 井手上 淳一 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (50642617) ; 吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747) ; 熊谷 雄一 鹿児島大学, 医学部・歯学部附属病院, その他 (40572160)
• Co-Investigator(Renkei-kenkyūsha): HIGASHI Michiyo 鹿児島大学, 医歯学域付属病院, 准教授 (60315405)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 膵臓癌 / 放射線化学療法 / 治療効果 / 予後 / CT / MRI / 酸素代謝

Outline of Final Research Achievements

We established blood oxygenation level-dependent contrast magnetic resonance imaging for prediction of overall survival in patients with pancreatic adenocarcinoma after chemoradiotherapy. Blood oxygenation level-dependent contrast magnetic resonance images were obtained in all patinets, but no significant association with treatment response or overall survival in pancreatic adenocarcinoma patients after chemoradiotherapy. However, we clarify the usefulness of extracellular volume fraction with equilibrium contrast-enhanced magnetic resonance imaging or multidetector computed tomography predicts outcomes for unresectable pancreatic adenocarcinoma patients treated with chemotherapy.

Free Research Field

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