The normal biodistribution of the short half life alpha radionuclide At-211 and the evaluation of thyroid cancer accumulation.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09955
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: SHIMOSEGAWA EKU 大阪大学, 医学系研究科, 寄附講座教授 (30370258)
• Co-Investigator(Kenkyū-buntansha): 池田 隼人 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (30649083) ; 金井 泰和 大阪大学, 医学系研究科, 寄附講座助教 (60397643) ; 畑澤 順 大阪大学, 医学系研究科, 教授 (70198745) ; 渡部 直史 大阪大学, 医学系研究科, 助教 (90648932)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アスタチン-211 / At-211 / 甲状腺摂取率 / α線 / アルファ線 / 甲状腺癌 / 内用療法 / 核医学治療

Outline of Final Research Achievements

The present study evaluated the distribution of At-211 by a daughter nuclide Po-211 imaging with gamma camera in normal rats, and revealed the physiological accumulation of At-211 of the thyroid gland and the stomach. We estimated thyroid and stomach uptake ratio of At-211 with comparing the difference between intravenous administration and oral intake. In addition, we evaluated At-211 accumulation in mice model of the thyroid cancer cell expressing the human Na/I symporter.

Free Research Field

核医学、放射線科学