2017 Fiscal Year Final Research Report
Development of Biodegradable Biostent for peripheral arterial disease
| Project/Area Number |
15K09968
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Research Collaborator |
Ichihashi Shigeo 奈良県立医科大学, 医学部, 学内講師 (60597102)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | PAD / IVR / EVT / Endothelial layer / Biostent / Biodegradable stent |
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| Outline of Final Research Achievements |
We have developed the Biostent concept in which the luminal surface of the stent is completely covered with the endothelial layer. The experiments were conducted using a biodegradable stents. However, due to the sparse mesh of the stent, breakage and deficiency of the fibrin membrane occurred when removing the metal rod after fibrin gel polymerization. We finally obtained the complete fibrin layer by Teflon coating on the surface of the metal rod. Then animal trials have been conducted using beagles. Isolation of endothelial cells of beagles was performed by exposing the femoral vein. The femoral vein had a small diameter of 2-3 mm in diameter, and the cut section further shrunk and shortened the vessel, so it was difficult to isolate the cells. After repeating the procedures, we succeeded in achieving endothelialization of the inner surface of the fibrin membrane. Currently the Biostent has been placed in jugular vein of beagles and under observation.
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| Free Research Field |
インターベンショナルラジオロジー
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