Fundamental study on percutaneous thoracic duct embolization for chylothorax: Establishment of animal model and evaluation of safety

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09971
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: INOUE Masanori 慶應義塾大学, 医学部(信濃町), 助教 (30338157)
• Co-Investigator(Kenkyū-buntansha): 小野澤 志郎 帝京大学, 医学部, 講師 (10544398) ; 中塚 誠之 慶應義塾大学, 医学部(信濃町), 講師 (50188984) ; 陣崎 雅弘 慶應義塾大学, 医学部(信濃町), 教授 (80216259) ; 米虫 敦 関西医科大学, 医学部, 講師 (80360254) ; 屋代 英樹 慶應義塾大学, 医学部, 共同研究員 (90327643)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 乳び胸水 / 胸管 / 塞栓術 / リンパ管造影

Outline of Final Research Achievements

We have established animal model of chylothorax associated with thoracic duct injury. Using this model, we embolized thoracic duct using metallic coils or NBCA. Five days after thoracic duct embolization, we performed lymphangiography again and confirmed that thoracic duct is completely embolized in both embolic materials. A part of jejunum and ileum was removed and a pathological specimen was prepared. Pathological examination confirmed the safely of thoracic duct embolization.

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