Investigation of the molecular mechanism of transiently elevated tumor uptake of PET tracers at early time points after X-ray radiation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: TSUJI Atsushi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー(定常) (60303559)
• Co-Investigator(Kenkyū-buntansha): 田畑 祥 慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 (30708342) ; 加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
• Research Collaborator: SUDO Hitomi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 研究員 (10415416) ; SUGYO Aya 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 技術員 (00415415)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: PET / 放射線

Outline of Final Research Achievements

Contribution of amino acid transporters for PET tracer uptake was markedly different among tumor cells, suggesting the possibility of a new uptake mechanism. Our findings in evaluation for tumor uptake after radiation, there was a need to develop a new PET tracer. Therefore, we developed and evaluated cysteine-based tracers in vitro and in vivo. To explorer pathways associated with the mechanism of transiently elevated uptake, metabolome analysis was conducted. Tumors treated with AIB and X-rays showed increased metabolites on the glycolysis. Our findings warrant further studies to investigate the mechanism of transiently elevated uptake after X-ray radiation.

Free Research Field

核医学