Development of a biological dose calculation system for spot-scanning proton therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09984
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Taeko Matsuura 北海道大学, 工学研究院, 准教授 (90590266)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 線エネルギー付与 / 陽子線治療 / 放射線生物効果

Outline of Final Research Achievements

This research focused on the spot-scanning proton therapy for tumors that move with respiration. We have established a methodology to calculate the delivered physical dose with the actual clinical setting. The methodology was implemented for the system developed in the AMED project, which enabled us to evaluate the actual dose delivered to patients on a daily basis. In addition, in order to evaluate the biological effect of proton beam with an emphasis on the dependency on the linear energy transfer (LET), we have developed an analytical LET calculation algorithm. This algorithm computes the LET distribution in patients in a few minutes rather than hours as in the Monte Carlo methods, while keeping the sufficiently good accuracy. Finally, since the dose rate can be another factor that influences the biological effect of proton beam we have developed a methodology to calculate the dose rate at arbitrary position in patients and prepared to the subsequent development of the research.

Free Research Field

陽子線治療物理